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Article

Integrating Pharmacogenomics and Network Topology for Machine Learning Prediction of HLA-Associated Severe Cutaneous Adverse Drug Reactions.

International journal of molecular sciences - 8 May 2026

Ponduan Tanaporn, Kunsombut Arisara, Paklao Thummarat, Suratanee Apichat, Pornputtapong Natapol, Plaimas Kitiporn

Abstract excerpt

Adverse drug reactions (ADRs) remain a major clinical challenge and a leading cause of morbidity and mortality worldwide. Among them, severe cutaneous adverse drug reactions (SCARs), including Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), represent life-threatening immune-mediated hypersensitivity responses strongly associated with specific human leukocyte antigen (HLA) alleles. Despite...

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Identifiers

PMID: 42196169
DOI: 10.3390/ijms27104187
PMCID: PMC13207861

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