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Article

ABCA1 mutation carriers with low high-density lipoprotein cholesterol are characterized by a larger atherosclerotic burden.

European heart journal - 1 Jan 2013

Bochem Andrea E, van Wijk Diederik F, Holleboom Adriaan G, Duivenvoorden Raphaël, Motazacker Mahdi M, Dallinga-Thie Geesje M, de Groot Eric, Kastelein John J P, Nederveen Aart J, Hovingh G Kees, Stroes Erik S G

Abstract excerpt

AIMS: Low HDL-C is a potent risk factor for cardiovascular disease (CVD). Yet, mutations in ABCA1, a major determinant of circulating HDL-C levels, were previously not associated with CVD risk in cohort studies. To study the consequences of low plasma levels of high-density lipoprotein cholesterol (HDL-C) due to ATP-binding cassette transporter A1 (ABCA1) dysfunction for atherosclerotic vascular disease in the...

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Share to ATP Binding Cassette Transporter 1
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23136402
DOI: 10.1093/eurheartj/ehs376

Genes

ABCA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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ABCA1 mutation carriers with low high-density lipoprotein cholesterol are characterized by a larger atherosclerotic burden.PMID 23136402Read ↗

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