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Article

Structure of a fully assembled γδ T cell antigen receptor

15 Aug 2024

Abstract excerpt

Abstract T cells in jawed vertebrates comprise two lineages, αβ T cells and γδ T cells, defined by the antigen receptors they express—that is, αβ and γδ T cell receptors (TCRs), respectively. The two lineages have different immunological roles, requiring that γδ TCRs recognize more structurally diverse ligands1. Nevertheless, the receptors use shared CD3 subunits to initiate signalling. Whereas the structural...

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PMID: 39146975
DOI: 10.1038/s41586-024-07920-0

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