Article

PRSS56 acts as an intrinsic retinal signal driving postnatal ocular axial growth and myopia susceptibility

2026-01-12

Abstract excerpt

Myopia is a leading cause of visual impairment worldwide, and high myopia markedly increases the risk of irreversible vision loss. Although visual experience guides postnatal ocular elongation, the role of intrinsic retinal growth signals remains poorly defined. Here we identify the serine protease PRSS56 as a retinal factor that promotes ocular axial growth beyond early development. Using genetic mouse models, we...

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Literature Corpus work: 6f886d3c-c360-544d-9ea7-c4e734b812ac
DOI: 10.64898/2026.01.11.697334

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