Article
Enhanced erythropoiesis mediated by activation of the renin-angiotensin system via angiotensin II type 1a receptor.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Dec 2005
Kato Hideki, Ishida Junji, Imagawa Shigehiko, Saito Tomoko, Suzuki Norio, Matsuoka Toshiki, Sugaya Takeshi, Tanimoto Keiji, Yokoo Takashi, Ohneda Osamu, Sugiyama Fumihiro, Yagami Ken-ichi, Fujita Toshiro, Yamamoto Masayuki, Nangaku Masaomi, Fukamizu Akiyoshi
Abstract excerpt
Although clinical and experimental studies have long suggested a role for the renin-angiotensin system (RAS) in the regulation of erythropoiesis, the molecular basis of this role has not been well understood. We report here that transgenic mice carrying both the human renin and human angiotensinogen genes displayed persistent erythrocytosis as well as hypertension. To identify the receptor molecule responsible...
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