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Host-virus molecular arms race: RNAi-mediated antiviral defense and viral suppressor of RNAi

27 Aug 2025

Abstract excerpt

RNA interference (RNAi) is a highly conserved post-transcriptional gene silencing (PTGS) mechanism widely presented in eukaryotes. During viral infection, double-stranded RNA viral replicative intermediate (vRI-dsRNA) derived from the viral genome is recognized and processed by Dicer to generate small interfering RNA (siRNA). The viral siRNA (vsiRNA) is subsequently loaded into the RNA-induced silencing complex...

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PMID: 40994739
DOI: 10.1016/j.cellin.2025.100276

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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