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Article

Frequency of alcohol consumption in humans; the role of metabotropic glutamate receptors and downstream signaling pathways.

Translational psychiatry - 23 Jun 2015

Meyers J L, Salling M C, Almli L M, Ratanatharathorn A, Uddin M, Galea S, Wildman D E, Aiello A E, Bradley B, Ressler K, Koenen K C

Abstract excerpt

Rodent models implicate metabotropic glutamate receptors (mGluRs) and downstream signaling pathways in addictive behaviors through metaplasticity. One way mGluRs can influence synaptic plasticity is by regulating the local translation of AMPA receptor trafficking proteins via eukaryotic elongation factor 2 (eEF2). However, genetic variation in this pathway has not been examined with human alcohol use phenotypes....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26101849
DOI: 10.1038/tp.2015.70
PMCID: PMC4490281

Genes

EEF2
GRM1
GRIA1
GRIA4
GRM5
HOMER2
MTOR
ARC
HOMER1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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