High-Fat Diet-Fed Kcnq1 Mutant Mice Have Reduced Pancreatic β-Cell Mass via Gene-Environment Interaction.

doi:10.4093/dmj.2024.0790

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Article

High-Fat Diet-Fed Kcnq1 Mutant Mice Have Reduced Pancreatic β-Cell Mass via Gene-Environment Interaction.

Diabetes & metabolism journal - 1 Jan 2026

Asahara Shun-Ichiro, Inoue Hiroyuki, Ihara Yuka, Teruyama Kyoko, Imai Asuka, Hara Chisako, Hara Mizuki, Seike Masako, Yokoi Aisha, Kido Nozomi, Suzuki Hirotaka, Kanno Ayumi, Inaba Yuka, Watanabe Hitoshi, Shioi Go, Kimura-Koyanagi Maki, Matsumoto Michihiro, Inoue Hiroshi, Nakayama Keiichi I, Ogawa Wataru, Kasuga Masato, Kido Yoshiaki

Abstract excerpt

BACKGRUOUND: The potassium voltage-gated channel subfamily Q member 1 (KCNQ1) gene has recently received much attention as a candidate susceptibility gene for type 2 diabetes mellitus, especially in Asian populations. We previously reported that Kcnq1 mutant mice exhibit reduced insulin secretion and hyperglycemia due to a decrease in pancreatic β-cell mass. Through in vivo and in vitro analyses, we ascertained...

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Identifiers

PMID: 40734497
DOI: 10.4093/dmj.2024.0790
PMCID: PMC12813374

Genes

KCNQ1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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