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Cooperation of myocardin and smad2 in inducing differentiation of mesenchymal stem cells into smooth muscle cells

23 Feb 2012

Abstract excerpt

Several reports demonstrated that mesenchymal stem cells (MSCs) might differentiate into smooth muscle cells (SMCs) in vitro and in vivo. It has been shown that myocardin protein is a strong inducer of smooth muscle genes and MSCs can differentiate into SMCs in response to transforming growth factor-β (TGF-β). However, the relationship or link between myocardin and TGF-β3-induced MSC differentiation has not been...

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PMID: 22362485
DOI: 10.1002/iub.1003

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