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Article

Prolactin-stimulated survivin induction is required for beta cell mass expansion during pregnancy in mice.

Diabetologia - 1 Sept 2015

Xu Yili, Wang Xiaojing, Gao Li, Zhu Jiayu, Zhang Hui, Shi Houxia, Woo Minna, Wu Xiaohong

Abstract excerpt

AIMS/HYPOTHESIS: Prolactin (PRL)-stimulated beta cell proliferation is critical for maternal pancreatic beta cell mass expansion during pregnancy. However, the molecular effectors of the multiple putative signalling pathways downstream of the PRL receptor (PRL-R) are still elusive. Survivin has been shown to be induced during pregnancy. The aim of the present study was to define the essential role of survivin in...

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Source

Identifiers

PMID: 26099856
DOI: 10.1007/s00125-015-3670-0

Genes

PRL
INS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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