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Article

Lactogens promote beta cell survival through JAK2/STAT5 activation and Bcl-XL upregulation.

The Journal of biological chemistry - 19 Oct 2007

Fujinaka Yuichi, Takane Karen, Yamashita Hiroko, Vasavada Rupangi C

Abstract excerpt

One of the goals in the treatment for diabetes is to enhance pancreatic beta cell function, proliferation, and survival. This study explores the role of lactogenic hormones, prolactin (PRL) and placental lactogen (PL), in beta cell survival. We have previously shown that transgenic mice expressing mouse placental lactogen-1 (mPL1) in beta cells under the rat insulin II promoter (RIP) are resistant to the...

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Share to Anti-Inflammatory Agents
Share to bcl-X Protein
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Diabetes Mellitus, Experimental

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Source

Identifiers

PMID: 17728251
DOI: 10.1074/jbc.M702607200

Genes

JAK2
INS
PRL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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