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Article

Heterogenous MSH6 loss is a result of microsatellite instability within MSH6 and occurs in sporadic and hereditary colorectal and endometrial carcinomas.

The American journal of surgical pathology - 1 Oct 2015

Graham Rondell P, Kerr Sarah E, Butz Malinda L, Thibodeau Stephen N, Halling Kevin C, Smyrk Thomas C, Dina Michelle A, Waugh Victoria M, Rumilla Kandelaria M

Abstract excerpt

Mismatch-repair (MMR) immunohistochemistry is used to detect tumor MMR deficiency associated with high-level microsatellite instability (MSI). Rare tumors show heterogenous loss of mutS homolog 6 (MSH6) with immunohistochemistry, defined by areas of retained staining and separate areas of complete loss of staining. To investigate the clinical interpretation of this phenomenon, we identified 22 cases of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26099011
DOI: 10.1097/PAS.0000000000000459

Genes

MSH6
MLH1
PMS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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