Article
K63-Ubiquitylation and TRAF6 Pathways Regulate Mammalian P-Body Formation and mRNA Decapping.
Molecular cell - 16 Jun 2016
Tenekeci Ulas, Poppe Michael, Beuerlein Knut, Buro Christin, Müller Helmut, Weiser Hendrik, Kettner-Buhrow Daniela, Porada Katharina, Newel Doris, Xu Ming, Chen Zhijian J, Busch Julia, Schmitz M Lienhard, Kracht Michael
Abstract excerpt
Signals and posttranslational modifications regulating the decapping step in mRNA degradation pathways are poorly defined. In this study we reveal the importance of K63-linked ubiquitylation for the assembly of decapping factors, P-body formation, and constitutive decay of instable mRNAs encoding mediators of inflammation by various experimental approaches. K63-branched ubiquitin chains also regulate...
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