Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The papain-like protease of coronaviruses cleaves ULK1 to disrupt host autophagy

8 Jan 2021

Abstract excerpt

The ongoing pandemic of COVID-19 alongside the outbreaks of SARS in 2003 and MERS in 2012 underscore the significance to understand betacoronaviruses as a global health challenge. SARS-CoV-2, the etiological agent for COVID-19, has infected over 50 million individuals’ worldwide with more than ∼1 million fatalities. Autophagy modulators have emerged as potential therapeutic candidates against SARS-CoV-2 but...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to CRISPR and Genetic Engineering
Share to Mosquito-borne diseases and control

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33450483
DOI: 10.1016/j.bbrc.2020.12.091

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The papain-like protease of coronaviruses cleaves ULK1 to disrupt host autophagyPMID 33450483Read ↗

Coronavirus membrane-associated papain-like proteases induce autophagy through interacting with Beclin1 to negatively regulate antiviral innate immunitySemantic proximity Read ↗

Digesting the crisis: autophagy and coronavirusesSemantic proximity Read ↗

Role and clinical implication of autophagy in COVID-19Semantic proximity Read ↗

Suppression of SARS‐CoV‐2 infection in ex‐vivo human lung tissues by targeting class III phosphoinositide 3‐kinaseSemantic proximity Read ↗

Is Autophagy a Friend or Foe in SARS-CoV-2 Infection?Semantic proximity Read ↗

Autophagy, EVs, and Infections: A Perfect Question for a Perfect TimeSemantic proximity Read ↗

The coronavirus 3CL protease: Unveiling its complex host interactions and central role in viral pathogenesisSemantic proximity Read ↗

Autophagy and SARS-CoV-2-Old Players in New GamesSemantic proximity Read ↗

Coxsackievirus infection induces a non-canonical autophagy independent of the ULK and PI3K complexesSemantic proximity Read ↗

TRIM proteins: New players in virus-induced autophagySemantic proximity Read ↗

Targeting the Endocytic Pathway and Autophagy Process as a Novel Therapeutic Strategy in COVID-19Semantic proximity Read ↗

The substrate selectivity of papain-like proteases from human-infecting coronaviruses correlates with innate immune suppressionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.