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Article

Spatiotemporal Control of ULK1 Activation by NDP52 and TBK1 during Selective Autophagy

7 Mar 2019

Abstract excerpt

Selective autophagy recycles damaged organelles and clears intracellular pathogens to prevent their aberrant accumulation. How ULK1 kinase is targeted and activated during selective autophagic events remains to be elucidated. In this study, we used chemically inducible dimerization (CID) assays in tandem with CRISPR KO lines to systematically analyze the molecular basis of selective autophagosome biogenesis. We...

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PMID: 30853401
DOI: 10.1016/j.molcel.2019.02.010

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