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Article

Estrogen-related receptor γ causes osteoarthritis by upregulating extracellular matrix-degrading enzymes

11 Dec 2017

Abstract excerpt

The estrogen-related receptor (ERR) family of orphan nuclear receptor is composed of ERRα, ERRβ, and ERRγ, which are known to regulate various isoform-specific functions under normal and pathophysiological conditions. Here, we investigate the involvement of ERRs in the pathogenesis of osteoarthritis (OA) in mice. Among ERR family members, ERRγ is markedly upregulated in cartilage from human OA patients and...

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PMID: 29247173
DOI: 10.1038/s41467-017-01868-8

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