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Article

MicroRNA-137 Controls AMPA-Receptor-Mediated Transmission and mGluR-Dependent LTD.

Cell reports - 30 Jun 2015

Olde Loohuis Nikkie F M, Ba Wei, Stoerchel Peter H, Kos Aron, Jager Amanda, Schratt Gerhard, Martens Gerard J M, van Bokhoven Hans, Nadif Kasri Nael, Aschrafi Armaz

Abstract excerpt

Mutations affecting the levels of microRNA miR-137 are associated with intellectual disability and schizophrenia. However, the pathophysiological role of miR-137 remains poorly understood. Here, we describe a highly conserved miR-137-binding site within the mRNA encoding the GluA1 subunit of AMPA-type glutamate receptors (AMPARs) and confirm that GluA1 is a direct target of miR-137. Postsynaptic downregulation of...

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Identifiers

PMID: 26095359
DOI: 10.1016/j.celrep.2015.05.040

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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