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Article

The schizophrenia risk gene product miR-137 alters presynaptic plasticity.

Nature neuroscience - 1 Jul 2015

Siegert Sandra, Seo Jinsoo, Kwon Ester J, Rudenko Andrii, Cho Sukhee, Wang Wenyuan, Flood Zachary, Martorell Anthony J, Ericsson Maria, Mungenast Alison E, Tsai Li-Huei

Abstract excerpt

Noncoding variants in the human MIR137 gene locus increase schizophrenia risk with genome-wide significance. However, the functional consequence of these risk alleles is unknown. Here we examined induced human neurons harboring the minor alleles of four disease-associated single nucleotide polymorphisms in MIR137. We observed increased MIR137 levels compared to those in major allele-carrying cells. microRNA-137...

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Identifiers

PMID: 26005852
DOI: 10.1038/nn.4023
PMCID: PMC4506960

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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