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ABC transporters, cytochromes P450 and their main transcription factors: expression at the human blood–brain barrier

10 Oct 2008

Abstract excerpt

We have established the expression patterns of the genes encoding ATP-binding cassette (ABC) transporters and cytochromes P450 (CYPs) at the adult human blood-brain barrier (BBB) using isolated brain microvessels and cortex biopsies from patients with epilepsia or glioma. Microves synaptophysin (neurons) and neuron-glial antigen 2 (NG2) (pericytes). ABCG2 [breast cancer resistance protein (BCRP)] and ABCB1 (MDR1)...

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PMID: 19094056
DOI: 10.1111/j.1471-4159.2008.05720.x

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