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Mutagenesis breeding of high echinocandin B producing strain and further titer improvement with culture medium optimization.

Bioprocess and biosystems engineering - 1 Oct 2015

Zou Shu-Ping, Zhong Wei, Xia Chao-Jie, Gu Ya-Nan, Niu Kun, Zheng Yu-Guo, Shen Yin-Chu

Abstract excerpt

A combination of microbial strain improvement and statistical optimization is investigated to maximize echinocandin B (ECB) production from Aspergillus nidulans ZJB-0817. A classical sequential mutagenesis was studied first by using physical (ultraviolet irradiation at 254 nm) and chemical mutagens (lithium chloride and sodium nitrite). Mutant strain ULN-59 exhibited 2.1-fold increase in ECB production to...

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PMID: 26091897
DOI: 10.1007/s00449-015-1425-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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