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Article

Genetic modification of an echinocandin B-producing strain of Aspergillus nidulans to produce mutants blocked in sterigmatocystin biosynthesis.

Journal of industrial microbiology - 1 Nov 1994

Hodges R L, Hodges D W, Goggans K, Xuei X, Skatrud P, McGilvray D

Abstract excerpt

The production of echinocandin B (ECB), a lipopolypeptide used for chemical manufacture of the anti-Candida agent Cilofungin, was accomplished by fermentation using a strain of Aspergillus nidulans. In addition to ECB, this fermentation also produces a significant amount of sterigmatocystin (ST), a potent carcinogen structurally related to the aflatoxins. Mutants blocked in the ST biosynthetic pathway were...

Topics

Anti-Bacterial Agents
Aspergillus nidulans
Echinocandins
Fungal Proteins
Genes, Fungal
Genetic Engineering
Haploidy
Mutation
Peptides
Peptides, Cyclic
Sterigmatocystin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 7765669
DOI: 10.1007/BF01577222

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7765669-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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