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Article

Cooperative Electrostatic Interactions Drive Functional Evolution in the Alkaline Phosphatase Superfamily.

Journal of the American Chemical Society - 22 Jul 2015

Barrozo Alexandre, Duarte Fernanda, Bauer Paul, Carvalho Alexandra T P, Kamerlin Shina C L

Abstract excerpt

It is becoming widely accepted that catalytic promiscuity, i.e., the ability of a single enzyme to catalyze the turnover of multiple, chemically distinct substrates, plays a key role in the evolution of new enzyme functions. In this context, the members of the alkaline phosphatase superfamily have been extensively studied as model systems in order to understand the phenomenon of enzyme multifunctionality. In the...

Topics

Alkaline Phosphatase
Burkholderia
Catalytic Domain
Computer Simulation
Evolution, Molecular
Hydrogen-Ion Concentration
Models, Biological
Models, Molecular
Mutation
Protein Conformation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Quantum Theory

Rhizobium leguminosarum

Static Electricity

Substrate Specificity

Source

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Identifiers

PMID: 26091851
DOI: 10.1021/jacs.5b03945
PMCID: PMC4513756

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