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Article

Transition States and Control of Substrate Preference in the Promiscuous Phosphatase PP1.

Biochemistry - 1 Aug 2017

Chu Yuan, Williams Nicholas H, Hengge Alvan C

Abstract excerpt

Catalytically promiscuous enzymes are an attractive frontier for biochemistry, because enzyme promiscuities not only plausibly explain enzyme evolution through the mechanism of gene duplication but also could provide an efficient route to changing the catalytic function of proteins by mimicking this evolutionary process. PP1γ is an effectively promiscuous phosphatase for the hydrolysis of both monoanionic and...

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Identifiers

PMID: 28678475
DOI: 10.1021/acs.biochem.7b00441

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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