Article
Prebiotically plausible mechanisms increase compositional diversity of nucleic acid sequences.
Nucleic acids research - 1 May 2012
Derr Julien, Manapat Michael L, Rajamani Sudha, Leu Kevin, Xulvi-Brunet Ramon, Joseph Isaac, Nowak Martin A, Chen Irene A
Abstract excerpt
During the origin of life, the biological information of nucleic acid polymers must have increased to encode functional molecules (the RNA world). Ribozymes tend to be compositionally unbiased, as is the vast majority of possible sequence space. However, ribonucleotides vary greatly in synthetic yield, reactivity and degradation rate, and their non-enzymatic polymerization results in compositionally biased...
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