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Article

Modification by SUMOylation Controls Both the Transcriptional Activity and the Stability of Delta-Lactoferrin.

PloS one - 1 Jan 2015

Escobar-Ramirez Adelma, Vercoutter-Edouart Anne-Sophie, Mortuaire Marlène, Huvent Isabelle, Hardivillé Stephan, Hoedt Esthelle, Lefebvre Tony, Pierce Annick

Abstract excerpt

Delta-lactoferrin is a transcription factor, the expression of which is downregulated or silenced in case of breast cancer. It possesses antitumoral activities and when it is re-introduced in mammary epithelial cancer cell lines, provokes antiproliferative effects. It is posttranslationally modified and our earlier investigations showed that the O-GlcNAcylation/phosphorylation interplay plays a major role in the...

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Identifiers

PMID: 26090800
DOI: 10.1371/journal.pone.0129965
PMCID: PMC4474976

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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