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Article

PINK1 deficiency impairs osteoblast differentiation through aberrant mitochondrial homeostasis

25 Nov 2021

Abstract excerpt

BACKGROUND: PTEN-induced kinase 1 (PINK1) is a serine/threonine-protein kinase in mitochondria that is critical for mitochondrial quality control. PINK1 triggers mitophagy, a selective autophagy of mitochondria, and is involved in mitochondrial regeneration. Although increments of mitochondrial biogenesis and activity are known to be crucial during differentiation, data regarding the specific role of PINK1 in...

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PMID: 34823575
DOI: 10.1186/s13287-021-02656-4

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