Article
Adult IDH wild type astrocytomas biologically and clinically resolve into other tumor entities.
Acta neuropathologica - 1 Sept 2015
Reuss David E, Kratz Annekathrin, Sahm Felix, Capper David, Schrimpf Daniel, Koelsche Christian, Hovestadt Volker, Bewerunge-Hudler Melanie, Jones David T W, Schittenhelm Jens, Mittelbronn Michel, Rushing Elisabeth, Simon Matthias, Westphal Manfred, Unterberg Andreas, Platten Michael, Paulus Werner, Reifenberger Guido, Tonn Joerg-Christian, Aldape Kenneth, Pfister Stefan M, Korshunov Andrey, Weller Michael, Herold-Mende Christel, Wick Wolfgang, Brandner Sebastian, von Deimling Andreas
Abstract excerpt
IDH wild type (IDHwt) anaplastic astrocytomas WHO grade III (AA III) are associated with poor outcome. To address the possibilities of molecular subsets among astrocytoma or of diagnostic reclassification, we analyzed a series of 160 adult IDHwt tumors comprising 120 AA III and 40 diffuse astrocytomas WHO grade II (A II) for molecular hallmark alterations and established methylation and copy number profiles....
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