Comparison between molecular and histological IDH-wild-type glioblastoma and extensive subgroup analysis of IDH-wild-type astrocytic tumors without genomic glioblastoma-defining alterations.

doi:10.1007/s11060-026-05637-w

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Comparison between molecular and histological IDH-wild-type glioblastoma and extensive subgroup analysis of IDH-wild-type astrocytic tumors without genomic glioblastoma-defining alterations.

Journal of neuro-oncology - 10 Jun 2026

Seifert Anna M, Richter Sven, Sagerer André, Lemnian Ioana, Herold Sylvia, Brückmann Sascha, Emmanouilidis Dimitrios, Alkhatib Majd, Eyüpoglu Ilker Y, Williams Erik A, Cahill Daniel P, Juratli Tareq A

Abstract excerpt

PURPOSE: This study compares clinical characteristics and survival between molecular (MolGBM) and histological IDH-wild-type (IDH-WT) glioblastoma (HistGBM), and further characterizes histological lower-grade IDH-WT astrocytic tumors without genomic GBM-defining alterations. METHODS: Adult patients with histologically lower-grade IDH-WT astrocytoma (WHO grade 2-3) and available tumor tissue were included. Tumors...

Topics

Humans
Isocitrate Dehydrogenase
Glioblastoma
Female
Male
Brain Neoplasms
Middle Aged
Adult
Mutation
Telomerase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Aged

Astrocytoma

Biomarkers, Tumor

Prognosis

Follow-Up Studies

Survival Rate

DNA Methylation

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Identifiers

PMID: 42268435
DOI: 10.1007/s11060-026-05637-w
PMCID: PMC13253596

Genes

IDH1
TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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