Article
Use of single-cycle analysis to study rates and mechanisms of retroviral mutation.
Methods (San Diego, Calif.) - 1 Aug 1997
Yu H, Jetzt A E, Dougherty J P
Abstract excerpt
Retroviruses evolve at rapid rates. This allows them to escape immune surveillance, thwarts vaccine development, and leads to rapid emergence of drug-resistant virus. Information regarding the retroviral mutation rates and the underlying mechanisms of mutagenesis will undoubtedly expedite the dev...
Topics
- Animals
- DNA, Viral
- Genetic Techniques
- Genetic Vectors
- Mice
- Mutation
- Recombination, Genetic
- Retroviridae
- Transcription, Genetic
- Virus Replication