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Article

TRIM21 induces selective autophagic degradation of c-Myc and sensitizes regorafenib therapy in colorectal cancer.

Proceedings of the National Academy of Sciences of the United States of America - 15 Oct 2024

Ye Wen-Long, Huang Long, Yang Xiao-Qin, Wan Shan, Gan Wen-Juan, Yang Yun, He Xiao-Shun, Liu Feng, Guo Xin, Liu Yi-Xuan, Hu Guang, Li Xiu-Ming, Shi Wei-Yi, He Kuang, Wu Yue-Yue, Wu Wen-Xin, Lu Jun-Hou, Song Yu, Qu Chen-Jiang, Wu Hua

Abstract excerpt

Kirsten rat sarcoma virus (KRAS) mutation is associated with malignant tumor transformation and drug resistance. However, the development of clinically effective targeted therapies for KRAS-mutant cancer has proven to be a formidable challenge. Here, we report that tripartite motif-containing protein 21 (TRIM21) functions as a target of extracellular signal-regulated kinase 2 (ERK2) in KRAS-mutant colorectal...

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Identifiers

PMID: 39388269
DOI: 10.1073/pnas.2406936121
PMCID: PMC11494295

Genes

TRIM21
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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TRIM21 induces selective autophagic degradation of c-Myc and sensitizes regorafenib therapy in colorectal cancer.PMID 39388269Read ↗

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