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Article

Germline TP53 Mutations in Patients With Early-Onset Colorectal Cancer in the Colon Cancer Family Registry.

JAMA oncology - 1 May 2015

Yurgelun Matthew B, Masciari Serena, Joshi Victoria A, Mercado Rowena C, Lindor Noralane M, Gallinger Steven, Hopper John L, Jenkins Mark A, Buchanan Daniel D, Newcomb Polly A, Potter John D, Haile Robert W, Kucherlapati Raju, Syngal Sapna

Abstract excerpt

IMPORTANCE: Li-Fraumeni syndrome, usually characterized by germline TP53 mutations, is associated with markedly elevated lifetime risks of multiple cancers, and has been linked to an increased risk of early-onset colorectal cancer. OBJECTIVE: To examine the frequency of germline TP53 alterations in patients with early-onset colorectal cancer. DESIGN, SETTING, AND PARTICIPANTS: This was a multicenter...

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Identifiers

PMID: 26086041
DOI: 10.1001/jamaoncol.2015.0197
PMCID: PMC4465271

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APC
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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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