Article
Prevalence of early onset colorectal cancer in 397 patients with classic Li-Fraumeni syndrome.
Gastroenterology - 1 Jan 2006
Wong Patricia, Verselis Sigitas J, Garber Judy E, Schneider Katherine, DiGianni Lisa, Stockwell David H, Li Frederick P, Syngal Sapna
Abstract excerpt
BACKGROUND & AIMS: Hereditary colorectal cancer is associated most commonly with the hereditary nonpolyposis colorectal cancer or familial adenomatous polyposis syndromes. We investigated the prevalence of early onset colorectal cancer and the frequency of p53 germline mutations in 64 families from a Li-Fraumeni syndrome (LFS) registry. METHODS: Patients with documented colorectal cancer and a diagnosis at or...
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