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Article

TP53, a gene for colorectal cancer predisposition in the absence of Li-Fraumeni-associated phenotypes.

Gut - 1 Jun 2021

Terradas Mariona, Mur Pilar, Belhadj Sami, Woodward Emma R, Burghel George J, Munoz-Torres Pau M, Quintana Isabel, Navarro Matilde, Brunet Joan, Lazaro Conxi, Pineda Marta, Moreno Victor, Capella Gabriel, Evans D Gareth R, Valle Laura

Abstract excerpt

OBJECTIVE: Germline TP53 pathogenic (P) variants cause Li-Fraumeni syndrome (LFS), an aggressive multitumor-predisposing condition. Due to the implementation of multigene panel testing, TP53 variants have been detected in individuals without LFS suspicion, for example, patients with colorectal cancer (CRC). We aimed to decipher whether these findings are the result of detecting the background population...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 32998877
DOI: 10.1136/gutjnl-2020-321825

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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