Article
Spectrum and Excess Risk of Gastrointestinal Tumors in Li-Fraumeni Syndrome.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association - 1 Mar 2024
Hatton Jessica N, de Andrade Kelvin C, Frone Megan N, Savage Sharon A, Khincha Payal P
Abstract excerpt
Li-Fraumeni syndrome (LFS), linked to heterozygous germline pathogenic/likely pathogenic variants in TP53, confers exceptionally high cancer risk, including core cancers (sarcoma, breast, adrenocortical, and brain cancer) among many other cancer types.1 Colorectal cancer (CRC) is most common after the core and hematologic cancers, accounting for ∼2.8% of diagnoses. Stomach and esophageal cancers constitute...
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