Article
A Genome-Wide Scan Identifies Variants in NFIB Associated with Metastasis in Patients with Osteosarcoma.
Cancer discovery - 1 Sept 2015
Mirabello Lisa, Koster Roelof, Moriarity Branden S, Spector Logan G, Meltzer Paul S, Gary Joy, Machiela Mitchell J, Pankratz Nathan, Panagiotou Orestis A, Largaespada David, Wang Zhaoming, Gastier-Foster Julie M, Gorlick Richard, Khanna Chand, de Toledo Silvia Regina Caminada, Petrilli Antonio S, Patiño-Garcia Ana, Sierrasesúmaga Luis, Lecanda Fernando, Andrulis Irene L, Wunder Jay S, Gokgoz Nalan, Serra Massimo, Hattinger Claudia, Picci Piero, Scotlandi Katia, Flanagan Adrienne M, Tirabosco Roberto, Amary Maria Fernanda, Halai Dina, Ballinger Mandy L, Thomas David M, Davis Sean, Barkauskas Donald A, Marina Neyssa, Helman Lee, Otto George M, Becklin Kelsie L, Wolf Natalie K, Weg Madison T, Tucker Margaret, Wacholder Sholom, Fraumeni Joseph F, Caporaso Neil E, Boland Joseph F, Hicks Belynda D, Vogt Aurelie, Burdett Laurie, Yeager Meredith, Hoover Robert N, Chanock Stephen J, Savage Sharon A
Abstract excerpt
UNLABELLED: Metastasis is the leading cause of death in patients with osteosarcoma, the most common pediatric bone malignancy. We conducted a multistage genome-wide association study of osteosarcoma metastasis at diagnosis in 935 osteosarcoma patients to determine whether germline genetic variation contributes to risk of metastasis. We identified an SNP, rs7034162, in NFIB significantly associated with metastasis...
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