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Article

The NFIB‐ERO1A axis promotes breast cancer metastatic colonization of disseminated tumour cells

10 Mar 2021

Abstract excerpt

Metastasis is the main cause of deaths related to solid cancers. Active transcriptional programmes are known to regulate the metastatic cascade but the molecular determinants of metastatic colonization remain elusive. Using an inducible piggyBac (PB) transposon mutagenesis screen, we have shown that overexpression of the transcription factor nuclear factor IB (NFIB) alone is sufficient to enhance primary mammary...

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PMID: 33751828
DOI: 10.15252/emmm.202013162

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