Article
Loss of NF2 defines a genetic subgroup of non-FOS-rearranged osteoblastoma.
The journal of pathology. Clinical research - 1 Oct 2020
Saba Karim H, Cornmark Louise, Hofvander Jakob, Magnusson Linda, Nilsson Jenny, van den Bos Hilda, Spierings Diana Cj, Foijer Floris, Staaf Johan, Brosjö Otte, Sumathi Vaiyapuri P, Lam Suk Wai, Szuhai Karoly, Bovée Judith Vmg, Kovac Michal, Baumhoer Daniel, Styring Emelie, Nord Karolin H
Abstract excerpt
Osteoblastoma is a locally aggressive tumour of bone. Until recently, its underlying genetic features were largely unknown. During the past two years, reports have demonstrated that acquired structural variations affect the transcription factor FOS in a high proportion of cases. These rearrangements modify the terminal exon of the gene and are believed to stabilise both the FOS transcript and the encoded protein,...
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