Article
Validation of a Chromosome 14 Risk Haplotype for Idiopathic Epilepsy in the Belgian Shepherd Dog Found to Be Associated with an Insertion in the RAPGEF5 Gene.
Genes - 23 Jun 2022
Belanger Janelle M, Heinonen Tiina, Famula Thomas R, Mandigers Paul J J, Leegwater Peter A, Hytönen Marjo K, Lohi Hannes, Oberbauer Anita M
Abstract excerpt
An idiopathic epilepsy (IE) risk haplotype on canine chromosome (CFA) 14 has been reported to interact with the CFA37 common risk haplotype in the Belgian shepherd (BS). Additional IE cases and control dogs were genotyped for the risk haplotypes to validate these previous findings. In the new cohort, the interaction between the two regions significantly elevated IE risk. When the haplotypes were analyzed...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.