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Article

Genome-wide association studies in dogs and humans identify ADAMTS20 as a risk variant for cleft lip and palate.

PLoS genetics - 1 Mar 2015

Wolf Zena T, Brand Harrison A, Shaffer John R, Leslie Elizabeth J, Arzi Boaz, Willet Cali E, Cox Timothy C, McHenry Toby, Narayan Nicole, Feingold Eleanor, Wang Xioajing, Sliskovic Saundra, Karmi Nili, Safra Noa, Sanchez Carla, Deleyiannis Frederic W B, Murray Jeffrey C, Wade Claire M, Marazita Mary L, Bannasch Danika L

Abstract excerpt

Cleft lip with or without cleft palate (CL/P) is the most commonly occurring craniofacial birth defect. We provide insight into the genetic etiology of this birth defect by performing genome-wide association studies in two species: dogs and humans. In the dog, a genome-wide association study of 7...

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Source

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Identifiers

PMID: 25798845
DOI: 10.1371/journal.pgen.1005059
PMCID: PMC4370697

Genes

ADAMTS20
CLPS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25798845-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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