The carboxyl-terminal region is NOT essential for secreted and functional levels of coagulation factor X.

doi:10.1111/jth.13034

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Article

The carboxyl-terminal region is NOT essential for secreted and functional levels of coagulation factor X.

Journal of thrombosis and haemostasis : JTH - 1 Aug 2015

Branchini A, Baroni M, Burini F, Puzzo F, Nicolosi F, Mari R, Gemmati D, Bernardi F, Pinotti M

Abstract excerpt

BACKGROUND: The homologous coagulation factor X (FX), VII (FVII), IX (FIX) and protein C (PC) display striking differences in the carboxyl-terminus, with that of FX being the most extended. This region is essential for FVII, FIX and PC secretion. OBJECTIVES: To provide experimental evidence for the role of the FX carboxyl-terminus. METHODS: Recombinant FX (rFX) variants were expressed in multiple eukaryotic cell...

Topics

Animals
Blood Coagulation
Cricetinae
Factor X
HEK293 Cells
Hep G2 Cells
Hepatocytes
Humans
Mutagenesis, Site-Directed
Mutation
Partial Thromboplastin Time
Protein Structure, Tertiary
Prothrombin Time
Structure-Activity Relationship

Source

Open in PubMed

Identifiers

PMID: 26083275
DOI: 10.1111/jth.13034

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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