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Article

Expression of human blood coagulation factor XI: characterization of the defect in factor XI type III deficiency.

Blood - 15 Mar 1992

Meijers J C, Davie E W, Chung D W

Abstract excerpt

Human factor XI (FXI) is a blood coagulation factor participating in the early phase of the intrinsic pathway of blood coagulation. It circulates in blood as a glycoprotein composed of two identical chains held together by a single disulfide bond between the fourth apple domains. FXI has been expressed in baby hamster kidney (BHK) cells, where it was synthesized as a single-chain molecule that was converted to...

Topics

Amino Acid Sequence
Animals
Cell Line
Cricetinae
Factor XI
Factor XI Deficiency
Humans
Molecular Sequence Data
Mutation
Recombinant Proteins

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 1547342

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1547342-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Expression of human blood coagulation factor XI: characterization of the defect in factor XI type III deficiency.PMID 1547342Read ↗

Characterization of seven novel mutations causing factor XI deficiency.Semantic proximity Read ↗

Three dominant-negative mutations in factor XI-deficient patients.Semantic proximity Read ↗

Structure and function of factor XI.Semantic proximity Read ↗

Characterisation of five factor XI mutations.Semantic proximity Read ↗

Dominant factor XI deficiency caused by mutations in the factor XI catalytic domainSemantic proximity Read ↗

Factor XI deficiency in French Basques is caused predominantly by an ancestral Cys38Arg mutation in the factor XI geneSemantic proximity Read ↗

Characterization of mutations causing factor VII deficiency in 61 unrelated Israeli patients.Semantic proximity Read ↗

Structural interpretation of 42 mutations causing factor XI deficiency using homology modeling.Semantic proximity Read ↗

Of four mutations in the factor VII gene in Tunisian patients, one novel mutation (Ser339Phe) in three unrelated families abrogates factor X activation.Semantic proximity Read ↗

Structure/function analysis of human factor XII using recombinant deletion mutants. Evidence for an additional region involved in the binding to negatively charged surfaces.Semantic proximity Read ↗

Characterization of a heparin binding site on the heavy chain of factor XI.Semantic proximity Read ↗

The carboxyl-terminal region of factor IX is essential for its secretion.Semantic proximity Read ↗

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