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Article

In vitro expression of mutant factor VII proteins and characterization of their clinical significance.

Molecular medicine reports - 1 Feb 2018

Mashayekhi Amir, Shahbazi Shirin, Omrani Mirdavood, Mahdian Reza

Abstract excerpt

Factor VII (FVII) serves an essential role in the initiation of blood coagulation. Mutations in conserved residues within its serine protease domain may lead to dysregulated coagulation activity. The objective of the present study was to elucidate the impact of altering two conserved residues, H348R and S282R, on the functional properties of the FVII protein. The mutation‑harboring fragments were derived from...

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PMID: 29207137
DOI: 10.3892/mmr.2017.8158

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