Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutant p53 cooperates with the SWI/SNF chromatin remodeling complex to regulate VEGFR2 in breast cancer cells.

Genes & development - 15 Jun 2015

Pfister Neil T, Fomin Vitalay, Regunath Kausik, Zhou Jeffrey Y, Zhou Wen, Silwal-Pandit Laxmi, Freed-Pastor William A, Laptenko Oleg, Neo Suat Peng, Bargonetti Jill, Hoque Mainul, Tian Bin, Gunaratne Jayantha, Engebraaten Olav, Manley James L, Børresen-Dale Anne-Lise, Neilsen Paul M, Prives Carol

Abstract excerpt

Mutant p53 impacts the expression of numerous genes at the level of transcription to mediate oncogenesis. We identified vascular endothelial growth factor receptor 2 (VEGFR2), the primary functional VEGF receptor that mediates endothelial cell vascularization, as a mutant p53 transcriptional target in multiple breast cancer cell lines. Up-regulation of VEGFR2 mediates the role of mutant p53 in increasing cellular...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromatin Assembly and Disassembly
Share to Chromosomal Proteins, Non-Histone

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HT29 Cells

Share to MCF-7 Cells

Share to Nucleosomes

Share to Protein Conformation

Share to Tumor Suppressor Protein p53

Share to Vascular Endothelial Growth Factor Receptor-2

Source

Open in PubMed Open full text

Identifiers

PMID: 26080815
DOI: 10.1101/gad.263202.115
PMCID: PMC4495400

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

Mutant p53 cooperates with the SWI/SNF chromatin remodeling complex to regulate VEGFR2 in breast cancer cells.PMID 26080815Read ↗

The mutant p53-ID4 complex controls VEGFA isoforms by recruiting lncRNA MALAT1.Semantic proximity Read ↗

KDR activating mutations in human angiosarcomas are sensitive to specific kinase inhibitors.Semantic proximity Read ↗

The execution of the transcriptional axis mutant p53, E2F1 and ID4 promotes tumor neo-angiogenesis.Semantic proximity Read ↗

p53 mutants cooperate with HIF-1 in transcriptional regulation of extracellular matrix components to promote tumor progressionSemantic proximity Read ↗

SWI/SNF Complex in Vascular Smooth Muscle Cells and Its Implications in Cardiovascular PathologiesSemantic proximity Read ↗

Novel functional germline variants in the VEGF receptor 2 gene and their effect on gene expression and microvessel density in lung cancer.Semantic proximity Read ↗

SWI/SNF complex interacts with tumor suppressor p53 and is necessary for the activation of p53-mediated transcription.Semantic proximity Read ↗

A novel variant of VEGFR2 identified by a pan-cancer screening of recurrent somatic mutations in the catalytic domain of tyrosine kinase receptors enhances tumor growth and metastasis.Semantic proximity Read ↗

Inducible changes in cell size and attachment area due to expression of a mutant SWI/SNF chromatin remodeling enzyme.Semantic proximity Read ↗

Noonan syndrome/leukemia-associated gain-of-function mutations in SHP-2 phosphatase (PTPN11) enhance cell migration and angiogenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.