Article
SWI/SNF complex interacts with tumor suppressor p53 and is necessary for the activation of p53-mediated transcription.
The Journal of biological chemistry - 21 Jun 2002
Lee Daeyoup, Kim Jin Woo, Seo Taegun, Hwang Sun Gwan, Choi Eui-Ju, Choe Joonho
Abstract excerpt
The SWI/SNF complex is required for the transcription of several genes and has been shown to alter nucleosome structure in an ATP-dependent manner. The tumor suppressor protein p53 displays growth and transformation suppression functions that are frequently lost in mutant p53 proteins detected in...
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