Article
Simultaneous analysis of mutations and methylations in circulating cell-free DNA for hepatocellular carcinoma detection.
Science translational medicine - 23 Nov 2022
Wang Pei, Song Qianqian, Ren Jie, Zhang Weilong, Wang Yuting, Zhou Lin, Wang Dongmei, Chen Kun, Jiang Liping, Zhang Bochao, Chen Wanqing, Qu Chunfeng, Zhao Hong, Jiao Yuchen
Abstract excerpt
Cell-free DNA (cfDNA)-based liquid biopsy is a promising approach for the early detection of cancer. A major hurdle is the limited yield of cfDNA from one blood draw, limiting the use of most samples to one test of either mutation or methylation. Here, we develop a technology, Mutation Capsule Plus (MCP), which enables multiplex profiling of one cfDNA sample, including simultaneous detection of genetic and...
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