Article
Genetic Determinants of Methotrexate Toxicity in Tunisian Patients with Rheumatoid Arthritis: A Study of Polymorphisms Involved in the MTX Metabolic Pathway.
European journal of drug metabolism and pharmacokinetics - 1 Aug 2016
Chaabane Souhir, Marzouk Sameh, Akrout Rim, Ben Hamad Mariem, Achour Yosser, Rebai Ahmed, Keskes Leila, Fourati Hela, Bahloul Zouhir, Maalej Abdellatif
Abstract excerpt
BACKGROUND AND OBJECTIVE: Methotrexate (MTX) is a disease-modifying anti-rheumatic drug used in the treatment of rheumatoid arthritis (RA). It is the first line drug in the treatment of this disease. However, MTX-related adverse drug reactions (ADRs) are seen in 40 % of the patients. The aim of this study was to determine the impact of six genetic polymorphisms located in five genes encoding proteins involved in...
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