Article
Associations between single-nucleotide polymorphisms of RFC-1, GGH, MTHFR , TYMS, and TCII genes and the efficacy and toxicity of methotrexate treatment in patients with rheumatoid arthritis.
Polskie Archiwum Medycyny Wewnetrznej - 1 Jan 2015
Świerkot Jerzy, Ślęzak Ryszard, Karpiński Paweł, Pawłowska Justyna, Noga Leszek, Szechiński Jacek, Wiland Piotr
Abstract excerpt
INTRODUCTION: The differences in drug efficacy and adverse reactions may be caused by genetic variations in drug metabolism between individuals. OBJECTIVES: The aim of the study was to evaluate the effect of gene polymorphisms on the efficacy of therapy and side effects in patients with rheumatoid arthrit s (RA) treated with methotrexate (MTX). PATIENTS AND METHODS: A total of 273 Caucasian patients with RA were...
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