Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Label-Free Raman Spectroscopic Imaging Monitors the Integral Physiologically Relevant Drug Responses in Cancer Cells.

Analytical chemistry - 21 Jul 2015

El-Mashtoly Samir F, Yosef Hesham K, Petersen Dennis, Mavarani Laven, Maghnouj Abdelouahid, Hahn Stephan, Kötting Carsten, Gerwert Klaus

Abstract excerpt

Predictions about the cellular efficacy of drugs tested in vitro are usually based on the measured responses of a few proteins or signal transduction pathways. However, cellular proteins are highly coupled in networks, and observations of single proteins may not adequately reflect the in vivo cellular response to drugs. This might explain some large discrepancies between in vitro drug studies and drug responses...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Monoclonal
Share to ErbB Receptors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Multivariate Analysis

Share to Panitumumab

Share to ras Proteins

Share to Spectrum Analysis, Raman

Share to Structure-Activity Relationship

Share to Tumor Cells, Cultured

Source

Identifiers

PMID: 26075314
DOI: 10.1021/acs.analchem.5b01431

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Label-Free Raman Spectroscopic Imaging Monitors the Integral Physiologically Relevant Drug Responses in Cancer Cells.PMID 26075314Read ↗

Raman micro-spectroscopy monitors acquired resistance to targeted cancer therapy at the cellular levelSemantic proximity Read ↗

Imaging vs Nonimaging Raman Spectroscopy for High-Throughput Single-Cell Phenotyping.Semantic proximity Read ↗

A Multimodal Imaging Framework to Advance Phenotyping of Living Label-free Breast Cancer Cells.Semantic proximity Read ↗

In vitro prediction of the efficacy of molecularly targeted cancer therapy by Raman spectral imaging.Semantic proximity Read ↗

Tracking the EMT-like phenotype switching during targeted therapy in melanoma by analyzing extracellular vesicle phenotypes.Semantic proximity Read ↗

From Genotype to Phenotype: Raman Spectroscopy and Machine Learning for Label-Free Single-Cell Analysis.Semantic proximity Read ↗

In Situ Single Cell Proteomics Reveals Circulating Tumor Cell Heterogeneity during TreatmentSemantic proximity Read ↗

Raman-guided analysis of drug response combined with chemometrics helps monitor the effect of ruxolitinib on acute lymphoblastic leukemia.Semantic proximity Read ↗

VIP-OT: Dissecting Single-Cell Biochemical State Dynamics under Perturbation via Vibrational Painting and Optimal TransportSemantic proximity Read ↗

Research advances in Raman imaging of single-cell phenotypes in fatty acid metabolism in cancers.Semantic proximity Read ↗

Probing cancer signaling with resonant waveguide grating biosensorsSemantic proximity Read ↗

Label-free morpho-molecular phenotyping of living cancer cells by combined Raman spectroscopy and phase tomography.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.