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Article

Tracking the EMT-like phenotype switching during targeted therapy in melanoma by analyzing extracellular vesicle phenotypes.

Biosensors & bioelectronics - 15 Jan 2024

Zhou Quan, Wang Jing, Zhang Zhen, Wuethrich Alain, Lobb Richard J, Trau Matt

Abstract excerpt

Melanoma continues to be a leading cause of mortality among skin cancers. Despite advancements in targeted therapy, patients frequently develop resistance, leading to disease progression within a year. This resistance may result from the epithelial-to-mesenchymal transition (EMT)-like phenotype switching of melanoma cells. Tracking EMT-related phenotypic changes on extracellular vesicles (EVs) has potential to...

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Identifiers

PMID: 37952322
DOI: 10.1016/j.bios.2023.115819

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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