Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

In vitro prediction of the efficacy of molecularly targeted cancer therapy by Raman spectral imaging.

Analytical and bioanalytical chemistry - 1 Nov 2015

Yosef Hesham K, Mavarani Laven, Maghnouj Abdelouahid, Hahn Stephan, El-Mashtoly Samir F, Gerwert Klaus

Abstract excerpt

Mutational acquired resistance is a major challenge in cancer therapy. Somatic tumours harbouring some oncogenic mutations are characterised by a high mortality rate. Surprisingly, preclinical evaluation methods do not show clearly resistance of mutated cancers to some drugs. Here, we implemented Raman spectral imaging to investigate the oncogenic mutation resistance to epidermal growth factor receptor targeting...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Colon
Share to Colonic Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Erlotinib Hydrochloride

Share to HT29 Cells

Share to Microscopy, Confocal

Share to Molecular Targeted Therapy

Share to Proto-Oncogene Proteins p21(ras)

Share to Spectrum Analysis, Raman

Source

Open in PubMed Open full text

Identifiers

PMID: 26168967
DOI: 10.1007/s00216-015-8875-z
PMCID: PMC4604500

Genes

BRAF
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

In vitro prediction of the efficacy of molecularly targeted cancer therapy by Raman spectral imaging.PMID 26168967Read ↗

Raman micro-spectroscopy monitors acquired resistance to targeted cancer therapy at the cellular levelSemantic proximity Read ↗

Label-Free Raman Spectroscopic Imaging Monitors the Integral Physiologically Relevant Drug Responses in Cancer Cells.Semantic proximity Read ↗

Tracking the EMT-like phenotype switching during targeted therapy in melanoma by analyzing extracellular vesicle phenotypes.Semantic proximity Read ↗

Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling.Semantic proximity Read ↗

Long-Term Vemurafenib Exposure Induced Alterations of Cell Phenotypes in Melanoma: Increased Cell Migration and Its Association with EGFR ExpressionSemantic proximity Read ↗

In Vitro Biophysical and Biological Characterization of Lipid Nanoparticles Co-Encapsulating Oncosuppressors miR-199b-5p and miR-204-5p as Potentiators of Target Therapy in Metastatic Melanoma.Semantic proximity Read ↗

A multidimensional impedance platform for the real-time analysis of single and combination drug pharmacology in patient-derived viable melanoma models.Semantic proximity Read ↗

Clinical responses to ERK inhibition in BRAF V600E-mutant colorectal cancer predicted using a computational modelSemantic proximity Read ↗

Surface Enhanced Raman Spectroscopy (SERS) for the Multiplex Detection of Braf, Kras, and Pik3ca Mutations in Plasma of Colorectal Cancer Patients.Semantic proximity Read ↗

Combined SERS-Raman screening of HER2-overexpressing or silenced breast cancer cell linesSemantic proximity Read ↗

Nanoplasmonic Detection of EGFR Mutations Based on Extracellular Vesicle-Derived EGFR-Drug Interaction.Semantic proximity Read ↗

Facilitated Transport of EGFR Inhibitors Plays an Important Role in Their Cellular Uptake.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.